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Published: vendredi 14 juillet 2017


modern pharmacology is concerned with receptors that are present in the plasma membrane of cells. Physicians are familiar with the dopaminergic hypothesis of schizophrenia, the implication Nike Mercurial Superfly V of aminergic receptor dysfunction in depression, and the role of H2 receptors in stomach acid production. The relationship between nicotinic acetylcholine receptors and disease is not as well known, although these proteins have been studied extensively.





The goal of this review is to introduce the reader to the nAChR, as well as to describeChaussure football Nike Mercurial  how aberrations in its structure, function, and expression may be involved in the pathophysiology of a number of disease states including autosomal dominant nocturnal frontal lobe epilepsy the slow channel congenital myasthenic syndromes Alzheimer's disease , and schizophrenia. acetylcholine receptors comprise a class of pentameric (containing five subunits) ligandgated ion channels present in the central and peripheral nervous systems Based on several lines of evidence, each receptor subunit can be functionally and structurally divided into a number of domains The Nterminal region of the protein is exposed to the extracellular space and contains the ligandbinding domain in certain subunits (see below). Proceeding from this domain towards the Cterminus, the peptide chain is believed to traverse the lipid bilayer four times and both ends of the protein therefore face the extracellular space The second transmembrane domain lines the channel pore, and its amino acids determine the channel's ionic selectivity

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